Does taking Azathioprine affect pregnancy? For these reasons, before you start taking azathioprine it is important that your doctor or pharmacist knows: If you are pregnant, trying for a baby or breastfeeding. Some medicines are not suitable for people with certain conditions, and sometimes a medicine may only be used if extra care is taken. Our findings are comparable with other studies which have similarly examined the use of AZA/6-MP in IBD women during pregnancy. Azathioprine should not be started de novo in pregnant women; its long latency to therapeutic effect would make this an illogical choice for immunosuppression in this setting. Azathioprine has a good safety profile in pregnancy. 72 In a prospective observational study in 189 pregnant … Alstead EM, Ritchie JK, Lennard-Jones JE, et al. New Reply Follow New Topic. Dr. Heidi Fowler answered. In animal studies, the drug increased the risk of certain birth defects. Is azathioprine safe in pregnancy and breastfeeding? Azathioprine is probably safe in all of these situations. best sellers. 0items $0.00. 0 comment. However, you should always discuss azathioprine use with your doctor in advance of planning any pregnancy. Azathioprine is commonly used in Crohn’s disease. Does it affect the baby. The objective of this study was to evaluate the risk of adverse fetal outcome in systemic lupus erythematosus (SLE) women exposed to azathioprine during pregnancy. 0. The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Azathioprine. Angrybird Moderator. Azathioprine is normally converted to the active metabolite 6-mercaptopurine. Azathioprine should be used during pregnancy only if the potential benefit justifies the potential risk. If you’re planning a family or become pregnant while taking azathioprine, you should discuss this with your doctor as soon as possible. This seems to have worked, but I have recently found out that I am pregnant and am concerned about the effects on the baby. I’m 10 weeks gone now and I did stop taking my medication but my consultant is adamant that it won’t cause the baby any harm. Revisiting the immunomodulators tacrolimus, methotrexate, and mycophenolate mofetil: their mechanisms of action … Azathioprine crosses the placenta, but drug and metabolite concentrations are lower in the fetal circulation, suggesting placental metabolism. Gastroenterology 1990; 99:443. van Dieren JM, Kuipers EJ, Samsom JN, et al. If the benefits of treatment with azathioprine (for instance, to maintain remission during pregnancy) outweigh the risks, this drug may be continued during pregnancy… Women diagnosed with IBD and with prescriptions for azathioprine and/or corticosteroids, have an increased risk of LBW, pre-t … The most important thing is that your AIH is as controlled as well as possible during pregnancy. The patients were evaluated at least onc … Medscape - Indication-specific dosing for Azasan, Imuran (azathioprine), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. Therefore, azathioprine would be best avoided unless there is no alternative treatment. Ever since, I was on some medications in order to control my disease. Transplant patients immunosuppressed with azathioprine should not discontinue it on becoming pregnant. Unlike mercaptopurine,' , =, 3 a closely related analogue, azathioprine has been found to have no teratogenic activity in the rat .4 However, the present study, previously reported in part,' has demonstrated a profound effect of the drug on pregnancy in … 6, 13, 14 In a retrospective cohort study by Francella et al. We reviewed the medical records of SLE pregnant women followed from January 2005 to April 2013. I was taking 75mg to begin with then I found out that I was pregnant about 2-3 months after starting the treatment (4weeks until due date now) and my rheumatologist then lowered my dose to 50mg as I was nervous about carrying on taking medication whilst being pregnant … Men are also fine to continue taking it when trying for a baby. Azathioprine is a prodrug that is converted by hepatic xanthine oxidase to its active metabolite 6-mercaptopurine (6-MP). I have been taking Azathioprine for nearly a year now. Send thanks to the doctor. Safety of azathioprine in pregnancy in inflammatory bowel disease. Before taking azathioprine. Key clinical point: Monotherapy with azathioprine and anti-TNF agents can be continued in pregnancy with IBD to maintain remission.Major finding: Congenital anomalies were not higher in children with exposure to azathioprine, anti-TNF agents, or combination therapy, compared with no drug exposure (1 Azathioprine (Imuran) in Pregnancy/Lactation I have been taking this drug for 4 years to control Crohn's Disease related problems. marjy33405 over a year ago. Azathioprine falls into category D. It has been shown that use of azathioprine in pregnant women caused some babies to be born with problems. While azathioprine is probably safe in all of these situations, you must always discuss azathioprine use with your doctor before planning a pregnancy. Immunomodulators, such as Azathioprine (Imuran®), 6-mercaptopurine (6-MP, Purinethol®), and cyclosporine A (Sandimmune®, Neoral®), appear low risk during pregnancy in standard Do you have to come off the tablets before becoming pregnant? home. We reviewed the medical records of SLE pregnant women followed from January 2005 to April 2013. 0 thank. I was taking 75mg but he said I … The immunosuppressive agent azathioprine is considered a pregnancy category D drug, with some evidence of increased risk of fetal abnormalities in human studies. 6, there was no reported increase in prematurity, spontaneous abortion, congenital anomalies, or neonatal and childhood infections in patients who were exposed to 6-MP prior to and during pregnancy … Immunomodulators. Do not take double or extra doses.This medicine may also interact with the following medications:This list may not describe all possible interactions. 6, 9-11 Furthermore, supported by animal and human data (on renal transplant recipients only), the use of azathioprine in pregnancy may be related to intrauterine growth … azathioprine in pregnancy . However, in pregnancy the placenta can metabolize azathioprine to thiouric acid, an inactive metabolite. The patients were evaluated at least … Also known as AZA, AZTP, Imuran (tn) A purine analogue with cytotoxic and immunosuppressive activity. By marjy33405 | 1 post, last post over a year ago. Overall, azathioprine concentration in breast milk is very low and mothers taking azathioprine may breast feed; any detectable concentration of azathioprine … However, there have been reports of premature birth and low birth-weight following exposure to azathioprine, particularly in combination with corticosteroids. If you become pregnant while taking this drug, call your doctor right away. INTRODUCTION: The use of azathioprine (AZA) in the treatment of autoimmune diseases during pregnancy are believed to be relatively safe, particularly taking into account the potential risks for mother and fetus should the underlying disease become active due to withdrawal of this thiopurine. View 2 more answers. The objective of this study was to evaluate the risk of adverse fetal outcome in systemic lupus erythematosus (SLE) women exposed to azathioprine during pregnancy. Although azathioprine has been reported to be safe during pregnancy in renal transplant recipients and patients with systemic lupus erythematosus, opinions vary whether it should be continued in pregnancy in inflammatory bowel disease. A retrospective analysis of the outcome of 16 pregnancies in 14 women receiving azathioprine … In addition the fetal liver does not have inosinatopyrophosphorylase which therefore largely protects the fetus from … Imuran (azathioprine): Imuran (azathioprine) is FDA pregnancy category D (Positive evidence of risk) 2 doctors agree. Currently, infants born to mothers taking azathioprine in pregnancy do not routinely have their haemoglobin level measured. 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